Publications & Projects

You can also find my publications on Google Scholar.
Publications are listed in chronological order.
2024

  • Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen
    K He, H Xiao, et al
    Nature Immunology
    Link to Paper

  • Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD
    J Su*, H Xiao*, et al
    JCI Insight, * represent equal contribution
    Link to Paper

  • Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis
    A Saha, T Chakraborty, J Rahimikollu, H Xiao, et al
    Science Translational Medicine
    Link to Paper

  • Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis
    N Natarajan, J Florentin, E Johny, H Xiao, et al
    Nature Communications
    Link to Paper

  • Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells
    S Grebinoski, G Pieklo, Q Zhang, A Visperas, J Cui, J Goulet, H Xiao, et al

    Nature Communications
    Link to Paper

  • SLIDE: Significant Latent Factor Interaction Discovery and Exploration across biological domains
    J Rahimikollu *, H Xiao*, et al
    Nature Method, * represent equal contribution
    Link to Paper

2023

  • Contextualized Networks Reveal Heterogeneous Transcriptomic Regulation in Tumors at Sample-Specific Resolution
    C Ellington, B Lengerich, TWatkins, J Yang, H Xiao, et al
    BioArxiv,
    Link to Paper

  • From bench to bedside via bytes: Multi-omic immunoprofiling and integration using machine learning and network approaches
    H Xiao, et al
    Human Vaccines & Immunotherapeutics,
    Link to Paper

  • Cell Type–Specific Biomarkers of Systemic Sclerosis Disease Severity Capture Cell-Intrinsic and Cell-Extrinsic Circuits
    J Berkowitz, T Tabib, H Xiao, et al
    Arthritis & Rheumatoogy
    Link to Paper

  • Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming
    V Kalia, J Reed, A Khanna, R Toumi, H Xiao, et al
    BioArxiv
    Link to Paper

  • Programming of checkpoint blockade responsive exhausted T cells by rheostatic IL-2 signals during priming by dendritic cells
    S Sarkar, R Toumi, H Xiao, et al
    The Joutnal of Immunology
    Link to Paper

2022

  • Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
    S Grebinoski, Q Zhang, A Cillo, S Manne, H Xiao, et al
    Nature Immunology
    Link to Paper

  • Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19
    E Brauns, A Azouz, D Grimaldi, H Xiao, et al
    JCI Insight
    Link to Paper

  • Early heterogeneity of IL2R□ expression influences the programming of exhausted CD8T cells during chronic infection
    R Toumi, H Xiao, et al
    Journal of Immunology
    Link to Paper

2021

  • Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory
    R Toumi, Y Yuzefpolskiy, A Vegaraju, H Xiao, et al
    Cell Reports
    Link to Paper

  • Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice
    V Kalia, Y Yuzefpolskiy, A Vegaraju, H Xiao, et al
    Science Translational Medicine
    Link to Paper

2020

  • PD-1 Signals are Critical for Homeostatic Maintenance of Memory CD8 T Cells
    S Sarkar, Y Yuzefpolskiy, A Vegaraju, H Xiao, et al
    The Journal of Immunology
    Link to Paper

2019

  • IL-2 Signals Program the Fate of Exhausted CD8 T cells
    V Kalia, H Xiao, et al
    The Journal of Immunology
    Link to Paper

2018

  • Programming of CD8 T cell quantity and polyfunctionality by direct IL-1 signals
    S Sarkar, Y Yuzefpolskiy, H Xiao, et al
    The Journal of Immunology
    Link to Paper